SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 610,200 Value ($000) $9,135 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 803,200 Value ($000) $12,960 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 1,030,000 Value ($000) $23,978 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 1,055,000 Value ($000) $31,028 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 1,152,411 Value ($000) $27,093 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 1,105,200 Value ($000) $41,920 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 1,000,000 Value ($000) $21,520 Avg Close $13.78 Range $8.43 - $22.66

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	610,200	$9,135	$14.80	$10.91 - $19.20
Q1 2025	803,200	$12,960	$20.81	$16.13 - $26.01
Q4 2024	1,030,000	$23,978	$29.32	$22.37 - $40.26
Q3 2024	1,055,000	$31,028	$27.85	$23.00 - $32.41
Q2 2024	1,152,411	$27,093	$33.73	$22.19 - $40.84
Q1 2024	1,105,200	$41,920	$28.97	$18.54 - $47.97
Q4 2023	1,000,000	$21,520	$13.78	$8.43 - $22.66