SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

LOS ANGELES CAPITAL MANAGEMENT LLC's Holding History (CIK: 0001177206)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 12,882 Value ($000) $313 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 18,172 Value ($000) $305 Avg Close $16.31 Range $14.00 - $18.30

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	12,882	$313	$26.13	$15.86 - $35.31
Q3 2025	18,172	$305	$16.31	$14.00 - $18.30