SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2024

Shares 9,638 Value ($000) $224 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 9,803 Value ($000) $288 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 9,842 Value ($000) $231 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 13,355 Value ($000) $507 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 28,095 Value ($000) $605 Avg Close $13.78 Range $8.43 - $22.66

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2024	9,638	$224	$29.32	$22.37 - $40.26
Q3 2024	9,803	$288	$27.85	$23.00 - $32.41
Q2 2024	9,842	$231	$33.73	$22.19 - $40.84
Q1 2024	13,355	$507	$28.97	$18.54 - $47.97
Q4 2023	28,095	$605	$13.78	$8.43 - $22.66