SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,000,000 Value ($000) $32,760 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 1,000,000 Value ($000) $16,760 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 626,703 Value ($000) $9,382 Avg Close $14.80 Range $10.91 - $19.20

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,000,000	$32,760	$26.13	$15.86 - $35.31
Q3 2025	1,000,000	$16,760	$16.31	$14.00 - $18.30
Q2 2025	626,703	$9,382	$14.80	$10.91 - $19.20