SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 76,194 Value ($000) $2,496 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 408,199 Value ($000) $6,841 Avg Close $16.31 Range $14.00 - $18.30

Q4 2024

Shares 167,804 Value ($000) $3,906 Avg Close $29.32 Range $22.37 - $40.26

Q1 2024

Shares 319,563 Value ($000) $12,121 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 108,486 Value ($000) $2,335 Avg Close $13.78 Range $8.43 - $22.66

Q3 2023

Shares 37,813 Value ($000) $463 Avg Close $13.22 Range $9.53 - $18.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	76,194	$2,496	$26.13	$15.86 - $35.31
Q3 2025	408,199	$6,841	$16.31	$14.00 - $18.30
Q4 2024	167,804	$3,906	$29.32	$22.37 - $40.26
Q1 2024	319,563	$12,121	$28.97	$18.54 - $47.97
Q4 2023	108,486	$2,335	$13.78	$8.43 - $22.66
Q3 2023	37,813	$463	$13.22	$9.53 - $18.00