SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q1 2024

Shares 161,921 Value ($000) $6,142 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 20,252 Value ($000) $436 Avg Close $13.78 Range $8.43 - $22.66

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2024	161,921	$6,142	$28.97	$18.54 - $47.97
Q4 2023	20,252	$436	$13.78	$8.43 - $22.66