SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Sterling Capital Management LLC's Holding History (CIK: 0001329883)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,610 Value ($000) $53 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 1,214 Value ($000) $20 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 524 Value ($000) $8 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 629 Value ($000) $10 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 1,009 Value ($000) $23 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 115 Value ($000) $3 Avg Close $27.85 Range $23.00 - $32.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,610	$53	$26.13	$15.86 - $35.31
Q3 2025	1,214	$20	$16.31	$14.00 - $18.30
Q2 2025	524	$8	$14.80	$10.91 - $19.20
Q1 2025	629	$10	$20.81	$16.13 - $26.01
Q4 2024	1,009	$23	$29.32	$22.37 - $40.26
Q3 2024	115	$3	$27.85	$23.00 - $32.41