SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,621,620 Value ($000) $53,124 Avg Close $26.13 Range $15.86 - $35.31

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,621,620	$53,124	$26.13	$15.86 - $35.31