SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

ProShare Advisors LLC's Holding History (CIK: 0001357955)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,989 Value ($000) $524 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 10,678 Value ($000) $179 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 12,479 Value ($000) $187 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 11,378 Value ($000) $184 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 12,531 Value ($000) $292 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,989	$524	$26.13	$15.86 - $35.31
Q3 2025	10,678	$179	$16.31	$14.00 - $18.30
Q2 2025	12,479	$187	$14.80	$10.91 - $19.20
Q1 2025	11,378	$184	$20.81	$16.13 - $26.01
Q4 2024	12,531	$292	$29.32	$22.37 - $40.26