SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Zurcher Kantonalbank (Zurich Cantonalbank)'s Holding History (CIK: 0001368163)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,164 Value ($000) $366 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 10,874 Value ($000) $182 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 12,873 Value ($000) $193 Avg Close $14.80 Range $10.91 - $19.20

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,164	$366	$26.13	$15.86 - $35.31
Q3 2025	10,874	$182	$16.31	$14.00 - $18.30
Q2 2025	12,873	$193	$14.80	$10.91 - $19.20