SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Bank of New York Mellon Corp's Holding History (CIK: 0001390777)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 192,830 Value ($000) $6,317 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 135,960 Value ($000) $2,279 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 132,150 Value ($000) $1,978 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 114,240 Value ($000) $1,843 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 103,688 Value ($000) $2,414 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 104,806 Value ($000) $3,082 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 117,686 Value ($000) $2,767 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 6,050 Value ($000) $229 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	192,830	$6,317	$26.13	$15.86 - $35.31
Q3 2025	135,960	$2,279	$16.31	$14.00 - $18.30
Q2 2025	132,150	$1,978	$14.80	$10.91 - $19.20
Q1 2025	114,240	$1,843	$20.81	$16.13 - $26.01
Q4 2024	103,688	$2,414	$29.32	$22.37 - $40.26
Q3 2024	104,806	$3,082	$27.85	$23.00 - $32.41
Q2 2024	117,686	$2,767	$33.73	$22.19 - $40.84
Q1 2024	6,050	$229	$28.97	$18.54 - $47.97