SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Capital World Investors's Holding History (CIK: 0001422849)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 200,172 Value ($000) $6,558 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 200,172 Value ($000) $3,355 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 350,774 Value ($000) $5,251 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 350,774 Value ($000) $5,660 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 378,573 Value ($000) $8,813 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	200,172	$6,558	$26.13	$15.86 - $35.31
Q3 2025	200,172	$3,355	$16.31	$14.00 - $18.30
Q2 2025	350,774	$5,251	$14.80	$10.91 - $19.20
Q1 2025	350,774	$5,660	$20.81	$16.13 - $26.01
Q4 2024	378,573	$8,813	$29.32	$22.37 - $40.26