SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

SUSQUEHANNA INTERNATIONAL GROUP, LLP's Holding History (CIK: 0001446194)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,111 Value ($000) $200 Avg Close $26.13 Range $15.86 - $35.31

Q2 2025

Shares 59,816 Value ($000) $895 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 58,696 Value ($000) $947 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 23,089 Value ($000) $538 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 13,198 Value ($000) $388 Avg Close $27.85 Range $23.00 - $32.41

Q1 2024

Shares 101,503 Value ($000) $3,850 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,111	$200	$26.13	$15.86 - $35.31
Q2 2025	59,816	$895	$14.80	$10.91 - $19.20
Q1 2025	58,696	$947	$20.81	$16.13 - $26.01
Q4 2024	23,089	$538	$29.32	$22.37 - $40.26
Q3 2024	13,198	$388	$27.85	$23.00 - $32.41
Q1 2024	101,503	$3,850	$28.97	$18.54 - $47.97