SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

SIMPLEX TRADING, LLC's Holding History (CIK: 0001488542)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 145 Value ($000) $0 Avg Close $14.80 Range $10.91 - $19.20

Q4 2024

Shares 55 Value ($000) $0 Avg Close $29.32 Range $22.37 - $40.26

Q2 2024

Shares 64 Value ($000) $0 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	145	$0	$14.80	$10.91 - $19.20
Q4 2024	55	$0	$29.32	$22.37 - $40.26
Q2 2024	64	$0	$33.73	$22.19 - $40.84