SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Brevan Howard Capital Management LP's Holding History (CIK: 0001512857)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,198 Value ($000) $203 Avg Close $26.13 Range $15.86 - $35.31

Q4 2024

Shares 16,899 Value ($000) $393 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,198	$203	$26.13	$15.86 - $35.31
Q4 2024	16,899	$393	$29.32	$22.37 - $40.26