SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

MetLife Investment Management, LLC's Holding History (CIK: 0001529735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 38,011 Value ($000) $1,245 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 29,918 Value ($000) $501 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 29,918 Value ($000) $448 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 23,733 Value ($000) $383 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 21,382 Value ($000) $498 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 20,132 Value ($000) $592 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 8,788 Value ($000) $207 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	38,011	$1,245	$26.13	$15.86 - $35.31
Q3 2025	29,918	$501	$16.31	$14.00 - $18.30
Q2 2025	29,918	$448	$14.80	$10.91 - $19.20
Q1 2025	23,733	$383	$20.81	$16.13 - $26.01
Q4 2024	21,382	$498	$29.32	$22.37 - $40.26
Q3 2024	20,132	$592	$27.85	$23.00 - $32.41
Q2 2024	8,788	$207	$33.73	$22.19 - $40.84