SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Assenagon Asset Management S.A.'s Holding History (CIK: 0001546007)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 22,136 Value ($000) $725 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 22,136 Value ($000) $371 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 22,136 Value ($000) $331 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 22,726 Value ($000) $367 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 22,652 Value ($000) $527 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 1,142,768 Value ($000) $33,609 Avg Close $27.85 Range $23.00 - $32.41

Q1 2024

Shares 64,400 Value ($000) $2,443 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	22,136	$725	$26.13	$15.86 - $35.31
Q3 2025	22,136	$371	$16.31	$14.00 - $18.30
Q2 2025	22,136	$331	$14.80	$10.91 - $19.20
Q1 2025	22,726	$367	$20.81	$16.13 - $26.01
Q4 2024	22,652	$527	$29.32	$22.37 - $40.26
Q3 2024	1,142,768	$33,609	$27.85	$23.00 - $32.41
Q1 2024	64,400	$2,443	$28.97	$18.54 - $47.97