SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

VOLORIDGE INVESTMENT MANAGEMENT, LLC's Holding History (CIK: 0001556921)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 264,317 Value ($000) $4,430 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 278,920 Value ($000) $4,175 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 257,432 Value ($000) $4,154 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 115,470 Value ($000) $2,688 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 156,481 Value ($000) $4,602 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 275,226 Value ($000) $6,471 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 188,053 Value ($000) $7,133 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	264,317	$4,430	$16.31	$14.00 - $18.30
Q2 2025	278,920	$4,175	$14.80	$10.91 - $19.20
Q1 2025	257,432	$4,154	$20.81	$16.13 - $26.01
Q4 2024	115,470	$2,688	$29.32	$22.37 - $40.26
Q3 2024	156,481	$4,602	$27.85	$23.00 - $32.41
Q2 2024	275,226	$6,471	$33.73	$22.19 - $40.84
Q1 2024	188,053	$7,133	$28.97	$18.54 - $47.97