SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Arizona State Retirement System's Holding History (CIK: 0001558481)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 13,797 Value ($000) $452 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 10,693 Value ($000) $179 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 10,512 Value ($000) $157 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 10,017 Value ($000) $162 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 10,115 Value ($000) $235 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 7,310 Value ($000) $215 Avg Close $27.85 Range $23.00 - $32.41

Q1 2024

Shares 5,445 Value ($000) $207 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	13,797	$452	$26.13	$15.86 - $35.31
Q3 2025	10,693	$179	$16.31	$14.00 - $18.30
Q2 2025	10,512	$157	$14.80	$10.91 - $19.20
Q1 2025	10,017	$162	$20.81	$16.13 - $26.01
Q4 2024	10,115	$235	$29.32	$22.37 - $40.26
Q3 2024	7,310	$215	$27.85	$23.00 - $32.41
Q1 2024	5,445	$207	$28.97	$18.54 - $47.97