SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Capital International Investors's Holding History (CIK: 0001562230)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,492,541 Value ($000) $114,416 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 2,392,541 Value ($000) $40,099 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 2,392,541 Value ($000) $35,816 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 2,392,541 Value ($000) $38,604 Avg Close $20.81 Range $16.13 - $26.01

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,492,541	$114,416	$26.13	$15.86 - $35.31
Q3 2025	2,392,541	$40,099	$16.31	$14.00 - $18.30
Q2 2025	2,392,541	$35,816	$14.80	$10.91 - $19.20
Q1 2025	2,392,541	$38,604	$20.81	$16.13 - $26.01