SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 96,057 Value ($000) $1,610 Avg Close $16.31 Range $14.00 - $18.30

Q3 2024

Shares 20,641 Value ($000) $607 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 11,551 Value ($000) $272 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 7,210 Value ($000) $273 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	96,057	$1,610	$16.31	$14.00 - $18.30
Q3 2024	20,641	$607	$27.85	$23.00 - $32.41
Q2 2024	11,551	$272	$33.73	$22.19 - $40.84
Q1 2024	7,210	$273	$28.97	$18.54 - $47.97