SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Point72 Asset Management, L.P.'s Holding History (CIK: 0001603466)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 662,351 Value ($000) $21,699 Avg Close $26.13 Range $15.86 - $35.31

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	662,351	$21,699	$26.13	$15.86 - $35.31