SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Russell Investments Group, Ltd.'s Holding History (CIK: 0001692234)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 5,554 Value ($000) $182 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 4,234 Value ($000) $71 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 142 Value ($000) $2 Avg Close $14.80 Range $10.91 - $19.20

Q3 2024

Shares 129 Value ($000) $4 Avg Close $27.85 Range $23.00 - $32.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	5,554	$182	$26.13	$15.86 - $35.31
Q3 2025	4,234	$71	$16.31	$14.00 - $18.30
Q2 2025	142	$2	$14.80	$10.91 - $19.20
Q3 2024	129	$4	$27.85	$23.00 - $32.41