SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Rockefeller Capital Management L.P.'s Holding History (CIK: 0001739439)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 549 Value ($000) $18 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 401 Value ($000) $7 Avg Close $16.31 Range $14.00 - $18.30

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	549	$18	$26.13	$15.86 - $35.31
Q3 2025	401	$7	$16.31	$14.00 - $18.30