SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Cinctive Capital Management LP's Holding History (CIK: 0001787258)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 35,935 Value ($000) $1,177 Avg Close $26.13 Range $15.86 - $35.31

Q4 2024

Shares 19,567 Value ($000) $456 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 61,256 Value ($000) $1,802 Avg Close $27.85 Range $23.00 - $32.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	35,935	$1,177	$26.13	$15.86 - $35.31
Q4 2024	19,567	$456	$29.32	$22.37 - $40.26
Q3 2024	61,256	$1,802	$27.85	$23.00 - $32.41