SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Polar Capital Holdings Plc's Holding History (CIK: 0001837309)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 740,326 Value ($000) $24,253 Avg Close $26.13 Range $15.86 - $35.31
Q3 2025
Shares 788,788 Value ($000) $13,220 Avg Close $16.31 Range $14.00 - $18.30
Q2 2025
Shares 745,000 Value ($000) $11,153 Avg Close $14.80 Range $10.91 - $19.20
Q1 2025
Shares 825,000 Value ($000) $13,311 Avg Close $20.81 Range $16.13 - $26.01
Q4 2024
Shares 750,000 Value ($000) $17,460 Avg Close $29.32 Range $22.37 - $40.26
Q3 2024
Shares 500,000 Value ($000) $14,705 Avg Close $27.85 Range $23.00 - $32.41
Q2 2024
Shares 500,000 Value ($000) $11,755 Avg Close $33.73 Range $22.19 - $40.84
Q1 2024
Shares 500,000 Value ($000) $18,965 Avg Close $28.97 Range $18.54 - $47.97
Q4 2023
Shares 500,000 Value ($000) $10,760 Avg Close $13.78 Range $8.43 - $22.66
Q3 2023
Shares 300,000 Value ($000) $3,675 Avg Close $13.22 Range $9.53 - $18.00