SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Darwin Global Management, Ltd.'s Holding History (CIK: 0001839209)

Note: Option positions (PUT/CALL) are excluded.

Q2 2024

Shares 452,040 Value ($000) $10,266 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 473,200 Value ($000) $17,948 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2024	452,040	$10,266	$33.73	$22.19 - $40.84
Q1 2024	473,200	$17,948	$28.97	$18.54 - $47.97