SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

TCG Crossover Management, LLC's Holding History (CIK: 0001839948)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,900,582 Value ($000) $62,263 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 1,100,582 Value ($000) $18,446 Avg Close $16.31 Range $14.00 - $18.30

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,900,582	$62,263	$26.13	$15.86 - $35.31
Q3 2025	1,100,582	$18,446	$16.31	$14.00 - $18.30