SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Paradigm Biocapital Advisors LP's Holding History (CIK: 0001855655)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,467,266 Value ($000) $48,068 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 1,467,266 Value ($000) $24,591 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 1,870,445 Value ($000) $28,001 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 2,127,205 Value ($000) $34,322 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 1,527,205 Value ($000) $35,553 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 1,267,581 Value ($000) $37,280 Avg Close $27.85 Range $23.00 - $32.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,467,266	$48,068	$26.13	$15.86 - $35.31
Q3 2025	1,467,266	$24,591	$16.31	$14.00 - $18.30
Q2 2025	1,870,445	$28,001	$14.80	$10.91 - $19.20
Q1 2025	2,127,205	$34,322	$20.81	$16.13 - $26.01
Q4 2024	1,527,205	$35,553	$29.32	$22.37 - $40.26
Q3 2024	1,267,581	$37,280	$27.85	$23.00 - $32.41