SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Nuveen, LLC's Holding History (CIK: 0001871926)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 150,980 Value ($000) $4,946 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 96,172 Value ($000) $1,612 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 135,068 Value ($000) $2,022 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 140,129 Value ($000) $2,261 Avg Close $20.81 Range $16.13 - $26.01

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	150,980	$4,946	$26.13	$15.86 - $35.31
Q3 2025	96,172	$1,612	$16.31	$14.00 - $18.30
Q2 2025	135,068	$2,022	$14.80	$10.91 - $19.20
Q1 2025	140,129	$2,261	$20.81	$16.13 - $26.01