SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Pictet Asset Management Holding SA's Holding History (CIK: 0001993888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 913,960 Value ($000) $29,941 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 1,036,218 Value ($000) $17,367 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 1,079,443 Value ($000) $16,159 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 1,068,892 Value ($000) $17,247 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 1,092,124 Value ($000) $25,425 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 825,706 Value ($000) $24,284 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 386,617 Value ($000) $9,089 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	913,960	$29,941	$26.13	$15.86 - $35.31
Q3 2025	1,036,218	$17,367	$16.31	$14.00 - $18.30
Q2 2025	1,079,443	$16,159	$14.80	$10.91 - $19.20
Q1 2025	1,068,892	$17,247	$20.81	$16.13 - $26.01
Q4 2024	1,092,124	$25,425	$29.32	$22.37 - $40.26
Q3 2024	825,706	$24,284	$27.85	$23.00 - $32.41
Q2 2024	386,617	$9,089	$33.73	$22.19 - $40.84