SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

BlackRock, Inc.'s Holding History (CIK: 0002012383)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 5,522,101 Value ($000) $180,904 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 3,982,744 Value ($000) $66,751 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 4,007,296 Value ($000) $59,989 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 3,572,674 Value ($000) $57,645 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 3,399,591 Value ($000) $79,142 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 2,663,147 Value ($000) $78,323 Avg Close $27.85 Range $23.00 - $32.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	5,522,101	$180,904	$26.13	$15.86 - $35.31
Q3 2025	3,982,744	$66,751	$16.31	$14.00 - $18.30
Q2 2025	4,007,296	$59,989	$14.80	$10.91 - $19.20
Q1 2025	3,572,674	$57,645	$20.81	$16.13 - $26.01
Q4 2024	3,399,591	$79,142	$29.32	$22.37 - $40.26
Q3 2024	2,663,147	$78,323	$27.85	$23.00 - $32.41