JADE BIOSCIENCES INC

Ticker: JBIO CUSIP: 008064206 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 14,012 Value ($000) $216 Avg Close $11.73 Range $8.16 - $17.71

Q3 2025

Shares 11,072 Value ($000) $96 Avg Close $8.17 Range $6.67 - $11.33

Q2 2025

Shares 11,420 Value ($000) $114 Avg Close $33.31 Range $6.57 - $97.54

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	14,012	$216	$11.73	$8.16 - $17.71
Q3 2025	11,072	$96	$8.17	$6.67 - $11.33
Q2 2025	11,420	$114	$33.31	$6.57 - $97.54