| FMR LLC | 6,894,488 | $106,382 |
| Fairmount Funds Management LLC | 4,553,494 | $70,260 |
| RA CAPITAL MANAGEMENT, L.P. | 3,671,083 | $56,645 |
| Bellevue Group AG | 3,341,103 | $51,553 |
| VR Adviser, LLC | 3,220,364 | $49,690 |
| BlackRock, Inc. | 2,870,313 | $44,289 |
| VANGUARD GROUP INC | 2,095,767 | $32,338 |
| BAKER BROS. ADVISORS LP | 1,641,137 | $25,323 |
| Remedium Capital Partners, LLC | 1,577,750 | $24 |
| Versant Venture Management, LLC | 1,525,820 | $23,543 |
| RTW INVESTMENTS, LP | 1,449,273 | $22,362 |
| Avidity Partners Management LP | 1,400,708 | $21,613 |
| Samsara BioCapital, LLC | 968,798 | $14,949 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 887,179 | $13,689 |
| MARSHALL WACE, LLP | 875,273 | $13,505 |
| abrdn plc | 867,284 | $13,382 |
| GEODE CAPITAL MANAGEMENT, LLC | 841,808 | $12,991 |
| GREAT POINT PARTNERS LLC | 806,273 | $12,441 |
| Soleus Capital Management, L.P. | 796,744 | $12,294 |
| Affinity Asset Advisors, LLC | 714,956 | $11,032 |
| STATE STREET CORP | 642,921 | $9,920 |
| Point72 Asset Management, L.P. | 558,474 | $8,617 |
| ORBIMED ADVISORS LLC | 531,163 | $8,196 |
| Opaleye Management Inc. | 427,608 | $6,598 |
| Logos Global Management LP | 395,000 | $6,095 |
| Ikarian Capital, LLC | 300,000 | $4,629 |
| Caption Management, LLC | 297,095 | $4,584 |
| ExodusPoint Capital Management, LP | 287,587 | $4,437 |
| NORTHERN TRUST CORP | 274,101 | $4,229 |
| Invesco Ltd. | 199,727 | $3,082 |
| AMERIPRISE FINANCIAL INC | 187,254 | $2,889 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,772 | $1,941 |
| Nuveen, LLC | 124,545 | $1,922 |
| Bank of New York Mellon Corp | 114,906 | $1,773 |
| Sofinnova Investments, Inc. | 107,391 | $1,657 |
| WELLINGTON MANAGEMENT GROUP LLP | 102,620 | $1,583 |
| UBS Group AG | 96,786 | $1,493 |
| Woodline Partners LP | 82,056 | $1,266 |
| BOOTHBAY FUND MANAGEMENT, LLC | 81,148 | $1,252 |
| MORGAN STANLEY | 79,767 | $1,231 |
| BARCLAYS PLC | 72,194 | $1,114 |
| RENAISSANCE TECHNOLOGIES LLC | 69,601 | $1,074 |
| Connor, Clark & Lunn Investment Management Ltd. | 67,230 | $1,037 |
| GOLDMAN SACHS GROUP INC | 65,340 | $1,008 |
| MILLENNIUM MANAGEMENT LLC | 62,809 | $969 |
| 9823 Capital, L.P. | 53,191 | $821 |
| WELLS FARGO & COMPANY/MN | 51,892 | $801 |
| RHUMBLINE ADVISERS | 50,053 | $772 |
| ALLIANCEBERNSTEIN L.P. | 45,334 | $700 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39,279 | $611 |
| BANK OF AMERICA CORP /DE/ | 37,512 | $579 |
| CITADEL ADVISORS LLC | 36,055 | $556 |
| DEUTSCHE BANK AG\ | 34,455 | $532 |
| Quantinno Capital Management LP | 29,492 | $455 |
| XTX Topco Ltd | 28,821 | $445 |
| MetLife Investment Management, LLC | 26,069 | $402 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,169 | $0 |
| TUDOR INVESTMENT CORP ET AL | 24,200 | $373 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 21,570 | $212 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,520 | $332 |
| ADAR1 Capital Management, LLC | 21,000 | $324 |
| JPMORGAN CHASE & CO | 20,599 | $318 |
| Virtus Investment Advisers, LLC | 17,759 | $274 |
| TWO SIGMA INVESTMENTS, LP | 16,496 | $255 |
| DELTEC ASSET MANAGEMENT LLC | 15,756 | $243 |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,622 | $226 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,012 | $216 |
| Persistent Asset Partners Ltd | 12,469 | $192 |
| Police & Firemen's Retirement System of New Jersey | 12,097 | $187 |
| INTECH INVESTMENT MANAGEMENT LLC | 11,802 | $182 |
| BNP PARIBAS ARBITRAGE, SA | 9,869 | $152 |
| Russell Investments Group, Ltd. | 5,932 | $92 |
| GROUP ONE TRADING, L.P. | 4,195 | $65 |
| Legal & General Group Plc | 4,130 | $64 |
| Ameritas Investment Partners, Inc. | 3,312 | $51 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,850 | $44 |
| Sterling Capital Management LLC | 2,667 | $41 |
| ROYAL BANK OF CANADA | 1,491 | $23 |
| AMALGAMATED BANK | 1,454 | $0 |
| CITIGROUP INC | 1,335 | $21 |
| Tower Research Capital LLC (TRC) | 1,252 | $19 |
| STRS OHIO | 900 | $14 |
| NISA INVESTMENT ADVISORS, LLC | 471 | $7 |
| Versant Capital Management, Inc | 393 | $6 |
| GAMMA Investing LLC | 357 | $6 |
| UBS ASSET MANAGEMENT AMERICAS INC | 210 | $3 |
| SIGNATUREFD, LLC | 128 | $2 |
| Aster Capital Management (DIFC) Ltd | 95 | $1 |
| PNC Financial Services Group, Inc. | 93 | $1 |
| EverSource Wealth Advisors, LLC | 89 | $1 |
| Farther Finance Advisors, LLC | 77 | $1 |
| SIMPLEX TRADING, LLC | 59 | $1 |
| CWM, LLC | 39 | $0 |
| Allworth Financial LP | 24 | $0 |
| Larson Financial Group LLC | 23 | $0 |
| SBI Securities Co., Ltd. | 14 | $0 |
| ROTHSCHILD INVESTMENT LLC | 9 | $0 |
| Avion Wealth | 7 | $0 |
| Capital Advisors, Ltd. LLC | 6 | $0 |
| Torren Management, LLC | 5 | $0 |
| 5 other institutions | 10 | $0 |