JADE BIOSCIENCES INC

Ticker: JBIO CUSIP: 008064206 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,496 Value ($000) $255 Avg Close $11.73 Range $8.16 - $17.71

Q3 2025

Shares 24,610 Value ($000) $212 Avg Close $8.17 Range $6.67 - $11.33

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,496	$255	$11.73	$8.16 - $17.71
Q3 2025	24,610	$212	$8.17	$6.67 - $11.33