AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

COMMERCE BANK's Holding History (CIK: 0001009076)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 12,656 Value ($000) $344 Avg Close $35.08 Range $22.24 - $46.00

Q3 2025

Shares 9,159 Value ($000) $368 Avg Close $37.61 Range $26.75 - $41.74

Q2 2025

Shares 9,604 Value ($000) $319 Avg Close $30.31 Range $23.42 - $36.39

Q1 2025

Shares 8,199 Value ($000) $240 Avg Close $33.17 Range $28.31 - $36.17

Q3 2024

Shares 6,069 Value ($000) $270 Avg Close $45.42 Range $40.80 - $53.29

Q2 2024

Shares 6,239 Value ($000) $269 Avg Close $36.09 Range $27.14 - $49.06

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	12,656	$344	$35.08	$22.24 - $46.00
Q3 2025	9,159	$368	$37.61	$26.75 - $41.74
Q2 2025	9,604	$319	$30.31	$23.42 - $36.39
Q1 2025	8,199	$240	$33.17	$28.31 - $36.17
Q3 2024	6,069	$270	$45.42	$40.80 - $53.29
Q2 2024	6,239	$269	$36.09	$27.14 - $49.06