| VANGUARD GROUP INC | 5,594,353 | $152,278 |
| BlackRock, Inc. | 5,235,429 | $142,508 |
| FARALLON CAPITAL MANAGEMENT LLC | 5,159,505 | $140,442 |
| STATE STREET CORP | 3,108,145 | $84,604 |
| ARMISTICE CAPITAL, LLC | 3,036,000 | $82,640 |
| Erste Asset Management GmbH | 2,804,900 | $76,343 |
| D. E. Shaw & Co., Inc. | 1,837,186 | $50,008 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,701,409 | $46,312 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,413,538 | $38,484 |
| BNP Paribas Investment Partners S.A. | 1,360,730 | $37 |
| CITADEL ADVISORS LLC | 1,348,968 | $36,719 |
| MPM BioImpact LLC | 1,303,373 | $35,478 |
| Frazier Life Sciences Management, L.P. | 1,279,754 | $34,835 |
| GW&K Investment Management, LLC | 1,207,301 | $33 |
| TCG Crossover Management, LLC | 1,181,841 | $32,170 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,142,432 | $31,097 |
| JANE STREET GROUP, LLC | 1,121,050 | $30,515 |
| GOLDMAN SACHS GROUP INC | 1,033,974 | $28,145 |
| DIMENSIONAL FUND ADVISORS LP | 1,004,341 | $27,338 |
| MORGAN STANLEY | 894,037 | $24,336 |
| Rock Springs Capital Management LP | 799,163 | $21,753 |
| Capital International Investors | 703,865 | $19,159 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 637,886 | $17 |
| BALYASNY ASSET MANAGEMENT L.P. | 635,069 | $17,287 |
| SCS Capital Management LLC | 598,765 | $16,298 |
| WELLINGTON MANAGEMENT GROUP LLP | 597,826 | $16,273 |
| Connor, Clark & Lunn Investment Management Ltd. | 562,642 | $15,315 |
| BANK OF AMERICA CORP /DE/ | 539,341 | $14,681 |
| Foresite Capital Management VI LLC | 530,000 | $14,427 |
| NORTHERN TRUST CORP | 511,901 | $13,934 |
| Artisan Partners Limited Partnership | 504,485 | $13,732 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 482,622 | $13,137 |
| ArrowMark Colorado Holdings LLC | 466,151 | $12,689 |
| ALGERT GLOBAL LLC | 414,218 | $11 |
| MILLENNIUM MANAGEMENT LLC | 398,267 | $10,841 |
| Qube Research & Technologies Ltd | 378,373 | $10,299 |
| MARSHALL WACE, LLP | 353,639 | $9,626 |
| Legal & General Group Plc | 328,211 | $8,934 |
| Vestal Point Capital, LP | 325,000 | $8,847 |
| BARCLAYS PLC | 320,352 | $8,720 |
| TWO SIGMA INVESTMENTS, LP | 300,156 | $8,170 |
| Nuveen, LLC | 297,908 | $8,109 |
| JPMORGAN CHASE & CO | 251,777 | $6,853 |
| BNP PARIBAS ARBITRAGE, SA | 242,670 | $6,605 |
| Trexquant Investment LP | 226,600 | $6,168 |
| Palo Alto Investors LP | 212,499 | $5,784 |
| Pictet Asset Management Holding SA | 205,019 | $5,569 |
| Point72 Asset Management, L.P. | 200,000 | $5,444 |
| Bank of New York Mellon Corp | 196,893 | $5,359 |
| ADAR1 Capital Management, LLC | 188,000 | $5,117 |
| Edgestream Partners, L.P. | 167,998 | $4,573 |
| GROUP ONE TRADING, L.P. | 166,614 | $4,535 |
| Tetragon Partners GP Ltd | 162,018 | $4,410 |
| AMERICAN CENTURY COMPANIES INC | 151,486 | $4,123 |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | $4,083 |
| Allianz Asset Management GmbH | 147,950 | $4,027 |
| HighVista Strategies LLC | 147,662 | $4,019 |
| HRT FINANCIAL LP | 146,469 | $4 |
| Invesco Ltd. | 142,580 | $3,881 |
| Exome Asset Management LLC | 136,942 | $3,728 |
| UBS Group AG | 126,665 | $3,448 |
| DEUTSCHE BANK AG\ | 122,875 | $3,345 |
| Squarepoint Ops LLC | 121,763 | $3,314 |
| Ikarian Capital, LLC | 115,489 | $3,144 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 111,150 | $3,026 |
| Assenagon Asset Management S.A. | 110,440 | $3,006 |
| Swiss National Bank | 108,860 | $2,963 |
| Rafferty Asset Management, LLC | 107,490 | $2,926 |
| UBS ASSET MANAGEMENT AMERICAS INC | 106,996 | $2,912 |
| Hudson Bay Capital Management LP | 100,000 | $2,722 |
| Parkman Healthcare Partners LLC | 99,604 | $2,711 |
| Caption Management, LLC | 93,486 | $2,545 |
| CITIGROUP INC | 88,238 | $2,402 |
| TWO SIGMA ADVISERS, LP | 85,200 | $2,319 |
| PRUDENTIAL FINANCIAL INC | 81,055 | $2,206 |
| PANAGORA ASSET MANAGEMENT INC | 79,840 | $2,173 |
| Y-Intercept (Hong Kong) Ltd | 79,831 | $2,173 |
| Lynx1 Capital Management LP | 79,624 | $2,167 |
| FIRST TRUST ADVISORS LP | 78,656 | $2,141 |
| Woodline Partners LP | 74,423 | $2,026 |
| RHUMBLINE ADVISERS | 74,153 | $2,018 |
| ExodusPoint Capital Management, LP | 71,146 | $1,937 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,256 | $1,917 |
| KENNEDY CAPITAL MANAGEMENT LLC | 65,655 | $1,787 |
| WELLS FARGO & COMPANY/MN | 64,772 | $1,763 |
| ALLIANCEBERNSTEIN L.P. | 61,494 | $1,674 |
| TUDOR INVESTMENT CORP ET AL | 61,345 | $1,670 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 60,560 | $1,648 |
| TD Asset Management Inc | 57,292 | $1,559 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,239 | $1,449 |
| Headlands Technologies LLC | 52,739 | $1,436 |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,707 | $1,407 |
| Engineers Gate Manager LP | 49,128 | $1,337 |
| ALPS ADVISORS INC | 47,881 | $1,303 |
| State of New Jersey Common Pension Fund D | 47,414 | $1,291 |
| SG Americas Securities, LLC | 46,451 | $1 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 46,242 | $1,264 |
| XTX Topco Ltd | 46,039 | $1,253 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 41,361 | $1,126 |
| Freestone Grove Partners LP | 40,841 | $1,112 |
| 136 other institutions | 1,479,946 | $36,876 |