AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

CANADA PENSION PLAN INVESTMENT BOARD's Holding History (CIK: 0001283718)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 18,200 Value ($000) $495 Avg Close $35.08 Range $22.24 - $46.00

Q2 2022

Shares 121 Value ($000) $3 Avg Close $22.59 Range $16.75 - $31.79

Q1 2022

Shares 121 Value ($000) $4 Avg Close $30.55 Range $26.51 - $35.12

Q4 2021

Shares 121 Value ($000) $4 Avg Close $40.25 Range $29.21 - $50.98

Q3 2021

Shares 727 Value ($000) $34 Avg Close $48.31 Range $40.99 - $58.61

Q2 2021

Shares 2,927 Value ($000) $161 Avg Close $55.92 Range $51.07 - $62.16

Q1 2021

Shares 6,845 Value ($000) $353 Avg Close $49.52 Range $42.87 - $58.93

Q4 2020

Shares 23,480 Value ($000) $1,017 Avg Close $39.54 Range $32.47 - $49.98

Q2 2020

Shares 32,886 Value ($000) $1,759 Avg Close $46.30 Range $34.08 - $54.53

Q1 2020

Shares 73,686 Value ($000) $2,614 Avg Close $46.21 Range $27.77 - $54.68

Q4 2019

Shares 92,386 Value ($000) $4,411 Avg Close $37.79 Range $28.36 - $50.74

Q3 2019

Shares 40,805 Value ($000) $1,322 Avg Close $41.40 Range $31.46 - $51.09

Q2 2019

Shares 21,766 Value ($000) $1,086 Avg Close $53.45 Range $45.43 - $68.89

Q4 2017

Shares 49,300 Value ($000) $2,818 Avg Close $62.92 Range $51.62 - $72.73

Q3 2017

Shares 45,900 Value ($000) $3,064 Avg Close $60.07 Range $50.91 - $67.72

Q2 2017

Shares 48,100 Value ($000) $2,475 Avg Close $51.12 Range $45.11 - $59.58

Q1 2017

Shares 30,500 Value ($000) $1,781 Avg Close $47.94 Range $39.24 - $58.65

Q4 2016

Shares 12,100 Value ($000) $505 Avg Close $52.47 Range $40.59 - $67.74

Q3 2016

Shares 14,500 Value ($000) $766 Avg Close $43.55 Range $35.84 - $54.99

Q2 2016

Shares 11,000 Value ($000) $461 Avg Close $49.39 Range $39.36 - $66.74

Q1 2016

Shares 11,100 Value ($000) $451 Avg Close $42.75 Range $33.50 - $66.87

Q4 2015

Shares 7,100 Value ($000) $461 Avg Close $65.59 Range $48.00 - $81.77

Q3 2015

Shares 800 Value ($000) $56 Avg Close $97.74 Range $67.52 - $120.96

Q2 2015

Shares 600 Value ($000) $67 Avg Close $107.71 Range $90.58 - $126.35

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	18,200	$495	$35.08	$22.24 - $46.00
Q2 2022	121	$3	$22.59	$16.75 - $31.79
Q1 2022	121	$4	$30.55	$26.51 - $35.12
Q4 2021	121	$4	$40.25	$29.21 - $50.98
Q3 2021	727	$34	$48.31	$40.99 - $58.61
Q2 2021	2,927	$161	$55.92	$51.07 - $62.16
Q1 2021	6,845	$353	$49.52	$42.87 - $58.93
Q4 2020	23,480	$1,017	$39.54	$32.47 - $49.98
Q2 2020	32,886	$1,759	$46.30	$34.08 - $54.53
Q1 2020	73,686	$2,614	$46.21	$27.77 - $54.68
Q4 2019	92,386	$4,411	$37.79	$28.36 - $50.74
Q3 2019	40,805	$1,322	$41.40	$31.46 - $51.09
Q2 2019	21,766	$1,086	$53.45	$45.43 - $68.89
Q4 2017	49,300	$2,818	$62.92	$51.62 - $72.73
Q3 2017	45,900	$3,064	$60.07	$50.91 - $67.72
Q2 2017	48,100	$2,475	$51.12	$45.11 - $59.58
Q1 2017	30,500	$1,781	$47.94	$39.24 - $58.65
Q4 2016	12,100	$505	$52.47	$40.59 - $67.74
Q3 2016	14,500	$766	$43.55	$35.84 - $54.99
Q2 2016	11,000	$461	$49.39	$39.36 - $66.74
Q1 2016	11,100	$451	$42.75	$33.50 - $66.87
Q4 2015	7,100	$461	$65.59	$48.00 - $81.77
Q3 2015	800	$56	$97.74	$67.52 - $120.96
Q2 2015	600	$67	$107.71	$90.58 - $126.35