AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 212,499 Value ($000) $5,784 Avg Close $35.08 Range $22.24 - $46.00

Q3 2025

Shares 265,497 Value ($000) $10,657 Avg Close $37.61 Range $26.75 - $41.74

Q2 2025

Shares 268,783 Value ($000) $8,940 Avg Close $30.31 Range $23.42 - $36.39

Q1 2025

Shares 276,578 Value ($000) $8,104 Avg Close $33.17 Range $28.31 - $36.17

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	212,499	$5,784	$35.08	$22.24 - $46.00
Q3 2025	265,497	$10,657	$37.61	$26.75 - $41.74
Q2 2025	268,783	$8,940	$30.31	$23.42 - $36.39
Q1 2025	276,578	$8,104	$33.17	$28.31 - $36.17