AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 353,639 Value ($000) $9,626 Avg Close $35.08 Range $22.24 - $46.00

Q3 2025

Shares 226,824 Value ($000) $9,105 Avg Close $37.61 Range $26.75 - $41.74

Q2 2025

Shares 684,669 Value ($000) $22,772 Avg Close $30.31 Range $23.42 - $36.39

Q1 2025

Shares 520,873 Value ($000) $15,262 Avg Close $33.17 Range $28.31 - $36.17

Q4 2024

Shares 631,628 Value ($000) $20,755 Avg Close $46.98 Range $32.31 - $62.58

Q3 2024

Shares 1,263,285 Value ($000) $56,128 Avg Close $45.42 Range $40.80 - $53.29

Q2 2024

Shares 1,133,735 Value ($000) $48,887 Avg Close $36.09 Range $27.14 - $49.06

Q1 2024

Shares 277,996 Value ($000) $8,129 Avg Close $26.78 Range $20.96 - $35.50

Q3 2023

Shares 58,040 Value ($000) $1,436 Avg Close $26.45 Range $24.04 - $28.65

Q3 2022

Shares 14,413 Value ($000) $408 Avg Close $26.82 Range $19.43 - $34.76

Q2 2022

Shares 43,563 Value ($000) $966 Avg Close $22.59 Range $16.75 - $31.79

Q4 2021

Shares 14,581 Value ($000) $479 Avg Close $40.25 Range $29.21 - $50.98

Q4 2020

Shares 43,878 Value ($000) $1,901 Avg Close $39.54 Range $32.47 - $49.98

Q3 2020

Shares 39,593 Value ($000) $1,386 Avg Close $43.83 Range $33.45 - $56.75

Q1 2020

Shares 55,234 Value ($000) $1,959 Avg Close $46.21 Range $27.77 - $54.68

Q4 2019

Shares 174,735 Value ($000) $8,344 Avg Close $37.79 Range $28.36 - $50.74

Q3 2019

Shares 71,260 Value ($000) $2,309 Avg Close $41.40 Range $31.46 - $51.09

Q4 2018

Shares 3,717 Value ($000) $171 Avg Close $61.72 Range $41.63 - $79.17

Q2 2018

Shares 5,490 Value ($000) $462 Avg Close $87.20 Range $72.14 - $99.82

Q1 2018

Shares 2,774 Value ($000) $227 Avg Close $77.29 Range $56.50 - $87.00

Q3 2017

Shares 9,587 Value ($000) $642 Avg Close $60.07 Range $50.91 - $67.72

Q4 2016

Shares 30,528 Value ($000) $1,274 Avg Close $52.47 Range $40.59 - $67.74

Q3 2016

Shares 107,423 Value ($000) $5,675 Avg Close $43.55 Range $35.84 - $54.99

Q1 2016

Shares 9,474 Value ($000) $385 Avg Close $42.75 Range $33.50 - $66.87

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	353,639	$9,626	$35.08	$22.24 - $46.00
Q3 2025	226,824	$9,105	$37.61	$26.75 - $41.74
Q2 2025	684,669	$22,772	$30.31	$23.42 - $36.39
Q1 2025	520,873	$15,262	$33.17	$28.31 - $36.17
Q4 2024	631,628	$20,755	$46.98	$32.31 - $62.58
Q3 2024	1,263,285	$56,128	$45.42	$40.80 - $53.29
Q2 2024	1,133,735	$48,887	$36.09	$27.14 - $49.06
Q1 2024	277,996	$8,129	$26.78	$20.96 - $35.50
Q3 2023	58,040	$1,436	$26.45	$24.04 - $28.65
Q3 2022	14,413	$408	$26.82	$19.43 - $34.76
Q2 2022	43,563	$966	$22.59	$16.75 - $31.79
Q4 2021	14,581	$479	$40.25	$29.21 - $50.98
Q4 2020	43,878	$1,901	$39.54	$32.47 - $49.98
Q3 2020	39,593	$1,386	$43.83	$33.45 - $56.75
Q1 2020	55,234	$1,959	$46.21	$27.77 - $54.68
Q4 2019	174,735	$8,344	$37.79	$28.36 - $50.74
Q3 2019	71,260	$2,309	$41.40	$31.46 - $51.09
Q4 2018	3,717	$171	$61.72	$41.63 - $79.17
Q2 2018	5,490	$462	$87.20	$72.14 - $99.82
Q1 2018	2,774	$227	$77.29	$56.50 - $87.00
Q3 2017	9,587	$642	$60.07	$50.91 - $67.72
Q4 2016	30,528	$1,274	$52.47	$40.59 - $67.74
Q3 2016	107,423	$5,675	$43.55	$35.84 - $54.99
Q1 2016	9,474	$385	$42.75	$33.50 - $66.87