AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

Flagship Pioneering, LLC's Holding History (CIK: 0001400240)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017

Shares 965,369 Value ($000) $56,378 Avg Close $47.94 Range $39.24 - $58.65

Q4 2016

Shares 965,369 Value ($000) $40,285 Avg Close $52.47 Range $40.59 - $67.74

Q3 2016

Shares 965,369 Value ($000) $50,991 Avg Close $43.55 Range $35.84 - $54.99

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2017	965,369	$56,378	$47.94	$39.24 - $58.65
Q4 2016	965,369	$40,285	$52.47	$40.59 - $67.74
Q3 2016	965,369	$50,991	$43.55	$35.84 - $54.99