AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,198 Value ($000) $250 Avg Close $35.08 Range $22.24 - $46.00

Q2 2025

Shares 8,646 Value ($000) $288 Avg Close $30.31 Range $23.42 - $36.39

Q4 2018

Shares 8,069 Value ($000) $372 Avg Close $61.72 Range $41.63 - $79.17

Q2 2017

Shares 4,630 Value ($000) $238 Avg Close $51.12 Range $45.11 - $59.58

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,198	$250	$35.08	$22.24 - $46.00
Q2 2025	8,646	$288	$30.31	$23.42 - $36.39
Q4 2018	8,069	$372	$61.72	$41.63 - $79.17
Q2 2017	4,630	$238	$51.12	$45.11 - $59.58