AGIOS PHARMACEUTICALS INC

Ticker: AGIO CUSIP: 00847X104 Class: Common Stock

SIMPLEX TRADING, LLC's Holding History (CIK: 0001488542)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,209 Value ($000) $169 Avg Close $35.08 Range $22.24 - $46.00

Q3 2023

Shares 21,006 Value ($000) $1 Avg Close $26.45 Range $24.04 - $28.65

Q2 2023

Shares 11,454 Value ($000) $0 Avg Close $24.88 Range $21.09 - $29.23

Q1 2023

Shares 14,834 Value ($000) $0 Avg Close $26.56 Range $21.07 - $31.56

Q3 2022

Shares 15,807 Value ($000) $447 Avg Close $26.82 Range $19.43 - $34.76

Q2 2022

Shares 9,810 Value ($000) $217 Avg Close $22.59 Range $16.75 - $31.79

Q4 2021

Shares 4,260 Value ($000) $140 Avg Close $40.25 Range $29.21 - $50.98

Q3 2021

Shares 5,715 Value ($000) $322 Avg Close $48.31 Range $40.99 - $58.61

Q2 2021

Shares 7,322 Value ($000) $403 Avg Close $55.92 Range $51.07 - $62.16

Q4 2020

Shares 13,337 Value ($000) $577 Avg Close $39.54 Range $32.47 - $49.98

Q3 2020

Shares 1,915 Value ($000) $67 Avg Close $43.83 Range $33.45 - $56.75

Q2 2020

Shares 2,183 Value ($000) $116 Avg Close $46.30 Range $34.08 - $54.53

Q3 2019

Shares 27,037 Value ($000) $875 Avg Close $41.40 Range $31.46 - $51.09

Q1 2019

Shares 1,133 Value ($000) $76 Avg Close $58.25 Range $44.37 - $68.94

Q4 2018

Shares 10,875 Value ($000) $501 Avg Close $61.72 Range $41.63 - $79.17

Q3 2018

Shares 4,418 Value ($000) $340 Avg Close $80.45 Range $70.47 - $94.39

Q2 2018

Shares 24,678 Value ($000) $2,078 Avg Close $87.20 Range $72.14 - $99.82

Q1 2018

Shares 16,234 Value ($000) $1,327 Avg Close $77.29 Range $56.50 - $87.00

Q4 2017

Shares 6,994 Value ($000) $399 Avg Close $62.92 Range $51.62 - $72.73

Q3 2017

Shares 37 Value ($000) $2 Avg Close $60.07 Range $50.91 - $67.72

Q4 2016

Shares 354 Value ($000) $14 Avg Close $52.47 Range $40.59 - $67.74

Q3 2016

Shares 27,905 Value ($000) $1,473 Avg Close $43.55 Range $35.84 - $54.99

Q2 2016

Shares 12,301 Value ($000) $515 Avg Close $49.39 Range $39.36 - $66.74

Q1 2016

Shares 9,933 Value ($000) $403 Avg Close $42.75 Range $33.50 - $66.87

Q4 2015

Shares 121 Value ($000) $7 Avg Close $65.59 Range $48.00 - $81.77

Q2 2015

Shares 1,130 Value ($000) $125 Avg Close $107.71 Range $90.58 - $126.35

Q4 2014

Shares 128 Value ($000) $14 Avg Close $89.28 Range $58.55 - $124.39

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,209	$169	$35.08	$22.24 - $46.00
Q3 2023	21,006	$1	$26.45	$24.04 - $28.65
Q2 2023	11,454	$0	$24.88	$21.09 - $29.23
Q1 2023	14,834	$0	$26.56	$21.07 - $31.56
Q3 2022	15,807	$447	$26.82	$19.43 - $34.76
Q2 2022	9,810	$217	$22.59	$16.75 - $31.79
Q4 2021	4,260	$140	$40.25	$29.21 - $50.98
Q3 2021	5,715	$322	$48.31	$40.99 - $58.61
Q2 2021	7,322	$403	$55.92	$51.07 - $62.16
Q4 2020	13,337	$577	$39.54	$32.47 - $49.98
Q3 2020	1,915	$67	$43.83	$33.45 - $56.75
Q2 2020	2,183	$116	$46.30	$34.08 - $54.53
Q3 2019	27,037	$875	$41.40	$31.46 - $51.09
Q1 2019	1,133	$76	$58.25	$44.37 - $68.94
Q4 2018	10,875	$501	$61.72	$41.63 - $79.17
Q3 2018	4,418	$340	$80.45	$70.47 - $94.39
Q2 2018	24,678	$2,078	$87.20	$72.14 - $99.82
Q1 2018	16,234	$1,327	$77.29	$56.50 - $87.00
Q4 2017	6,994	$399	$62.92	$51.62 - $72.73
Q3 2017	37	$2	$60.07	$50.91 - $67.72
Q4 2016	354	$14	$52.47	$40.59 - $67.74
Q3 2016	27,905	$1,473	$43.55	$35.84 - $54.99
Q2 2016	12,301	$515	$49.39	$39.36 - $66.74
Q1 2016	9,933	$403	$42.75	$33.50 - $66.87
Q4 2015	121	$7	$65.59	$48.00 - $81.77
Q2 2015	1,130	$125	$107.71	$90.58 - $126.35
Q4 2014	128	$14	$89.28	$58.55 - $124.39