ALDER BIOPHARMACEUTICALS INC

CUSIP: 014339105 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 65,000 Value ($000) $2,147 Avg Close — Range —
Q3 2015
Shares 16,100 Value ($000) $527 Avg Close — Range —