Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q4 2025 (← Previous)

Filing Date: Feb 17, 2026

Total Value ($000): $757,990 (100.0% shares, 0.0% debt)

Holdings (54)

New Positions (21)

CBIO CRESCENT BIOPHARMA INC 1.8%
Value ($000) $13,975 Shares 1,178,300 Est. Cost $12.74 Unrealized 0.0%
KPTI KARYOPHARM THERAPEUTICS INC 0.9%
Value ($000) $6,845 Shares 930,000 Est. Cost $6.12 Unrealized 0.0%
JBIO JADE BIOSCIENCES INC 0.9%
Value ($000) $6,598 Shares 427,608 Est. Cost $11.73 Unrealized 0.0%
URGN UROGEN PHARMA LTD 0.8%
Value ($000) $6,286 Shares 268,423 Est. Cost $21.69 Unrealized 0.0%
CATX PERSPECTIVE THERAPEUTICS INC 0.7%
Value ($000) $4,990 Shares 1,184,500 Est. Cost $2.85 Unrealized 0.0%
VYGR VOYAGER THERAPEUTICS INC 0.6%
Value ($000) $4,704 Shares 1,196,904 Est. Cost $3.93 Unrealized —
RLMD RELMADA THERAPEUTICS INC 0.6%
Value ($000) $4,516 Shares 935,000 Est. Cost $3.35 Unrealized 0.0%
TECX TECTONIC THERAPEUTICS INC 0.6%
Value ($000) $4,480 Shares 214,747 Est. Cost $18.58 Unrealized 0.0%
FBIO FORTRESS BIOTECH INC 0.5%
Value ($000) $3,989 Shares 1,090,000 Est. Cost $2.85 Unrealized 0.0%
RCKT ROCKET PHARMACEUTICALS INC 0.4%
Value ($000) $3,352 Shares 955,000 Est. Cost $3.42 Unrealized 0.0%
MGTX MEIRAGTX HOLDINGS PLC 0.4%
Value ($000) $3,107 Shares 390,844 Est. Cost $8.31 Unrealized 0.0%
— ASSERTIO HOLDINGS INC 0.3%
Value ($000) $2,585 Shares 285,000 Est. Cost $9.07 Unrealized —
VTYX VENTYX BIOSCIENCES INC 0.3%
Value ($000) $2,275 Shares 251,932 Est. Cost $7.47 Unrealized 0.0%
STRO SUTRO BIOPHARMA INC 0.3%
Value ($000) $2,206 Shares 190,671 Est. Cost $9.49 Unrealized 0.0%
— GENERATION BIO CO 0.2%
Value ($000) $1,761 Shares 310,000 Est. Cost $5.68 Unrealized —
BBIO BRIDGEBIO PHARMA INC 0.2%
Value ($000) $1,401 Shares 18,319 Est. Cost $65.64 Unrealized 0.0%
ENTA ENANTA PHARMACEUTICALS INC 0.2%
Value ($000) $1,183 Shares 75,000 Est. Cost $12.70 Unrealized 0.0%
QTTB Q32 BIO INC 0.1%
Value ($000) $708 Shares 213,363 Est. Cost $2.83 Unrealized 0.0%
AVIR ATEA PHARMACEUTICALS INC 0.1%
Value ($000) $642 Shares 179,815 Est. Cost $3.18 Unrealized 0.0%
SLN SILENCE THERAPEUTICS PLC 0.1%
Value ($000) $480 Shares 78,926 Est. Cost $6.08 Unrealized —
RAPT RAPT THERAPEUTICS INC 0.0%
Value ($000) $213 Shares 150,000 Est. Cost $31.06 Unrealized 0.0%

Increased Positions (14)

APGE APOGEE THERAPEUTICS INC 3.9%
Value ($000) $29,306 (+103.1%) Shares 388,257 (+6.9%) Est. Cost $39.78 Unrealized +58.3%
SLGL SOL GEL TECHNOLOGIES 2.5%
Value ($000) $19,121 (+220.2%) Shares 453,739 (+121.5%) Est. Cost $29.17 Unrealized +32.4%
ACOG ALPHA COGNITION INC 1.8%
Value ($000) $13,460 (+1695.7%) Shares 2,070,784 (+1698.5%) Est. Cost $6.47 Unrealized -2.4%
RZLT REZOLUTE INC 2.0%
Value ($000) $14,838 (+74.7%) Shares 6,287,156 (+595.9%) Est. Cost $7.31 Unrealized +7.2%
STOK STOKE THERAPEUTICS INC 2.9%
Value ($000) $22,059 (+37.6%) Shares 695,000 (+1.9%) Est. Cost $11.23 Unrealized +167.7%
MBX MBX BIOSCIENCES INC 1.1%
Value ($000) $8,200 (+85.2%) Shares 260,000 (+2.8%) Est. Cost $11.09 Unrealized +118.8%
IRON DISC MEDICINE INC 2.1%
Value ($000) $15,882 (+24.0%) Shares 200,000 (+3.2%) Est. Cost $52.27 Unrealized +61.7%
XOMA XOMA CORP DEL 1.0%
Value ($000) $7,780 (-20.9%) Shares 292,590 (+14.7%) Est. Cost $14.08 Unrealized +128.6%
RIGL RIGEL PHARMACEUTICALS INC 0.4%
Value ($000) $2,998 (+180.1%) Shares 70,000 (+85.2%) Est. Cost $33.50 Unrealized +12.5%
ZNTL ZENTALIS PHARMACEUTICALS INC 0.2%
Value ($000) $1,891 (+295.7%) Shares 1,400,906 (+342.6%) Est. Cost $1.88 Unrealized -22.5%
ZYME ZYMEWORKS INC 0.4%
Value ($000) $2,868 (+67.9%) Shares 108,929 (+8.9%) Est. Cost $14.04 Unrealized +55.3%
IRD OPUS GENETICS INC 0.3%
Value ($000) $2,251 (+24.0%) Shares 1,120,000 (+1.8%) Est. Cost $1.13 Unrealized +80.2%
ALKS ALKERMES PLC 1.8%
Value ($000) $13,710 (+1.6%) Shares 490,000 (+8.9%) Est. Cost $28.34 Unrealized +5.7%
CABA CABALETTA BIO INC 0.3%
Value ($000) $1,971 (+4.1%) Shares 900,000 (+11.3%) Est. Cost $1.79 Unrealized +38.2%

Exited Positions (10)

IMNM IMMUNOME INC 4.9%
Value ($000) $37,296 Shares 3,185,000 Est. Cost $12.21 Unrealized +43.7%
SRPT SAREPTA THERAPEUTICS INC 1.5%
Value ($000) $11,273 Shares 585,000 Est. Cost $39.05 Unrealized -46.0%
LRMR LARIMAR THERAPEUTICS INC 1.4%
Value ($000) $10,565 Shares 3,720,867 Est. Cost $2.71 Unrealized +43.6%
ARVN ARVINAS INC 1.1%
Value ($000) $8,416 Shares 987,818 Est. Cost $24.80 Unrealized -56.0%
TMCI TREACE MEDICAL CONCEPTS INC 0.6%
Value ($000) $4,712 Shares 702,245 Est. Cost $6.53 Unrealized -33.5%
— KARYOPHARM THERAPEUTICS INC 0.6%
Value ($000) $4,631 Shares 6,000,000 Est. Cost $0.62 Unrealized —
ADCT ADC Therapeutics SA 0.4%
Value ($000) $2,730 Shares 682,529 Est. Cost $3.15 Unrealized +28.7%
SYRE SPYRE THERAPEUTICS INC 0.1%
Value ($000) $1,089 Shares 65,000 Est. Cost $16.31 Unrealized +60.2%
PEPG PEPGEN INC 0.0%
Value ($000) $347 Shares 75,000 Est. Cost $4.62 Unrealized +12.4%
IBIO IBIO INC 0.0%
Value ($000) $310 Shares 375,000 Est. Cost $1.26 Unrealized +8.6%

Decreased Positions (6)

LQDA LIQUIDIA CORPORATION 11.2%
Value ($000) $84,982 (+42.9%) Shares 2,435,000 (-6.9%) Est. Cost $11.93 Unrealized +138.5%
CDXS CODEXIS INC 1.5%
Value ($000) $11,067 (-64.6%) Shares 6,789,738 (-46.9%) Est. Cost $2.81 Unrealized -27.4%
RYTM RHYTHM PHARMACEUTICALS INC 4.7%
Value ($000) $35,323 (-24.2%) Shares 330,000 (-28.5%) Est. Cost $12.73 Unrealized +733.2%
ALMS ALUMIS INC 0.7%
Value ($000) $5,222 (+96.8%) Shares 535,000 (-19.5%) Est. Cost $4.72 Unrealized +47.8%
PLX PROTALIX BIOTHERAPEUTICS INC 0.6%
Value ($000) $4,461 (-22.1%) Shares 2,478,176 (-4.0%) Est. Cost $1.63 Unrealized +25.5%
TRVI TREVI THERAPEUTICS INC 0.6%
Value ($000) $4,321 (+21.1%) Shares 345,100 (-11.5%) Est. Cost $2.06 Unrealized +461.8%

Unchanged Positions (13)

ETON ETON PHARMACEUTICALS INC 6.4%
Value ($000) $48,363 Shares 2,860,000 Est. Cost $5.71 Unrealized +208.1%
SNWV SANUWAVE HEALTH INC 3.9%
Value ($000) $29,281 Shares 981,267 Est. Cost $28.49 Unrealized +12.6%
ANNX ANNEXON INC 1.7%
Value ($000) $13,052 Shares 2,600,000 Est. Cost $2.48 Unrealized +54.0%
EWTX EDGEWISE THERAPEUTICS INC 1.6%
Value ($000) $12,408 Shares 500,000 Est. Cost $11.02 Unrealized +82.1%
TGTX TG THERAPEUTICS INC 2.1%
Value ($000) $15,948 Shares 535,000 Est. Cost $13.67 Unrealized +139.0%
RVMD REVOLUTION MEDICINES INC 1.1%
Value ($000) $7,965 Shares 100,000 Est. Cost $38.42 Unrealized +70.7%
HROW HARROW HEALTH INC 25.2%
Value ($000) $191,345 Shares 3,905,000 Est. Cost $6.33 Unrealized +562.8%
PTGX PROTAGONIST THERAPEUTICS INC 1.2%
Value ($000) $9,171 Shares 105,000 Est. Cost $17.50 Unrealized +367.8%
GOSS GOSSAMER BIO INC 1.1%
Value ($000) $8,432 Shares 2,720,000 Est. Cost $1.01 Unrealized +183.2%
OCUL OCULAR THERAPEUTIX INC 2.6%
Value ($000) $19,363 Shares 1,595,000 Est. Cost $5.10 Unrealized +138.4%
DERM JOURNEY MEDICAL CORP 1.0%
Value ($000) $7,517 Shares 975,000 Est. Cost $7.08 Unrealized +10.8%
CGON CG ONCOLOGY INC 2.2%
Value ($000) $17,023 Shares 410,000 Est. Cost $27.46 Unrealized +50.7%
ADGM ADAGIO MED HLDGS INC 0.0%
Value ($000) $115 Shares 110,571 Est. Cost $4.76 Unrealized -75.1%