ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

COMERICA BANK's Holding History (CIK: 0000901541)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,040 Value ($000) $1,607 Avg Close $442.56 Range $387.03 - $495.55

Q3 2025

Shares 11,790 Value ($000) $5,376 Avg Close $407.20 Range $309.57 - $484.21

Q2 2025

Shares 18,617 Value ($000) $6,071 Avg Close $276.71 Range $205.87 - $327.21

Q1 2025

Shares 17,253 Value ($000) $4,659 Avg Close $257.00 Range $230.79 - $300.90

Q4 2024

Shares 13,991 Value ($000) $3,292 Avg Close $262.99 Range $229.86 - $304.39

Q3 2024

Shares 1,912 Value ($000) $526 Avg Close $260.36 Range $231.01 - $287.55

Q2 2024

Shares 12,588 Value ($000) $3,059 Avg Close $157.87 Range $141.98 - $252.87

Q1 2024

Shares 13,003 Value ($000) $1,943 Avg Close $166.82 Range $143.52 - $199.38

Q4 2023

Shares 13,363 Value ($000) $2,558 Avg Close $170.34 Range $148.10 - $198.00

Q3 2023

Shares 13,426 Value ($000) $2,377 Avg Close $191.12 Range $168.65 - $218.88

Q4 2022

Shares 11,761 Value ($000) $3 Avg Close $213.29 Range $181.65 - $242.97

Q3 2022

Shares 11,727 Value ($000) $2,297 Avg Close $190.74 Range $135.46 - $236.80

Q2 2022

Shares 11,666 Value ($000) $1,700 Avg Close $141.87 Range $117.58 - $180.35

Q1 2022

Shares 11,666 Value ($000) $1,959 Avg Close $152.35 Range $125.00 - $174.66

Q4 2021

Shares 11,675 Value ($000) $1,529 Avg Close $185.86 Range $154.82 - $212.00

Q3 2021

Shares 11,677 Value ($000) $2,319 Avg Close $187.58 Range $166.16 - $209.73

Q2 2021

Shares 14,981 Value ($000) $2,951 Avg Close $146.46 Range $125.08 - $177.53

Q1 2021

Shares 15,177 Value ($000) $2,075 Avg Close $150.49 Range $124.00 - $178.41

Q4 2020

Shares 15,586 Value ($000) $2,686 Avg Close $133.53 Range $119.29 - $148.76

Q3 2020

Shares 15,931 Value ($000) $2,100 Avg Close $142.10 Range $119.67 - $167.33

Q2 2020

Shares 16,041 Value ($000) $2,534 Avg Close $134.81 Range $98.01 - $158.37

Q1 2020

Shares 20,787 Value ($000) $3,027 Avg Close $115.43 Range $84.97 - $134.51

Q4 2019

Shares 24,520 Value ($000) $2,831 Avg Close $99.70 Range $73.32 - $125.72

Q3 2019

Shares 25,816 Value ($000) $2,295 Avg Close $79.11 Range $69.11 - $88.00

Q2 2019

Shares 31,459 Value ($000) $2,286 Avg Close $76.72 Range $65.81 - $96.08

Q1 2019

Shares 27,303 Value ($000) $2,482 Avg Close $83.64 Range $70.29 - $93.95

Q4 2018

Shares 25,667 Value ($000) $2,031 Avg Close $76.92 Range $60.27 - $90.00

Q3 2018

Shares 22,088 Value ($000) $1,692 Avg Close $100.59 Range $86.95 - $124.22

Q2 2018

Shares 16,132 Value ($000) $1,649 Avg Close $99.19 Range $87.35 - $118.71

Q1 2018

Shares 16,110 Value ($000) $1,549 Avg Close $128.92 Range $108.13 - $153.99

Q4 2017

Shares 16,157 Value ($000) $2,164 Avg Close $125.65 Range $111.25 - $147.63

Q3 2017

Shares 15,885 Value ($000) $1,953 Avg Close $85.36 Range $70.76 - $119.02

Q2 2017

Shares 15,687 Value ($000) $1,310 Avg Close $63.91 Range $46.90 - $86.92

Q1 2017

Shares 15,741 Value ($000) $831 Avg Close $46.22 Range $35.98 - $60.41

Q4 2016

Shares 16,269 Value ($000) $677 Avg Close $41.87 Range $31.38 - $71.67

Q3 2016

Shares 13,557 Value ($000) $491 Avg Close $70.55 Range $53.56 - $80.11

Q2 2016

Shares 13,714 Value ($000) $1,048 Avg Close $63.00 Range $49.96 - $75.08

Q1 2016

Shares 13,683 Value ($000) $941 Avg Close $66.49 Range $51.51 - $98.00

Q4 2015

Shares 13,594 Value ($000) $1,151 Avg Close $92.72 Range $71.14 - $110.75

Q3 2015

Shares 13,827 Value ($000) $1,111 Avg Close $111.10 Range $76.46 - $137.89

Q2 2015

Shares 27,524 Value ($000) $3,298 Avg Close $119.50 Range $98.63 - $140.00

Q1 2015

Shares 13,710 Value ($000) $1,431 Avg Close $101.34 Range $82.06 - $121.93

Q4 2014

Shares 27,366 Value ($000) $2,654 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 13,683 Value ($000) $1,068 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 13,720 Value ($000) $867 Avg Close $59.44 Range $47.03 - $71.40

Q1 2014

Shares 18,260 Value ($000) $1,226 Avg Close $77.42 Range $60.24 - $112.57

Q4 2013

Shares 18,247 Value ($000) $1,174 Avg Close $59.65 Range $48.16 - $67.97

Q3 2013

Shares 19,791 Value ($000) $1,267 Avg Close $49.85 Range $31.75 - $65.83

Q2 2013

Shares 19,877 Value ($000) $616 Avg Close $26.61 Range $21.60 - $31.79

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,040	$1,607	$442.56	$387.03 - $495.55
Q3 2025	11,790	$5,376	$407.20	$309.57 - $484.21
Q2 2025	18,617	$6,071	$276.71	$205.87 - $327.21
Q1 2025	17,253	$4,659	$257.00	$230.79 - $300.90
Q4 2024	13,991	$3,292	$262.99	$229.86 - $304.39
Q3 2024	1,912	$526	$260.36	$231.01 - $287.55
Q2 2024	12,588	$3,059	$157.87	$141.98 - $252.87
Q1 2024	13,003	$1,943	$166.82	$143.52 - $199.38
Q4 2023	13,363	$2,558	$170.34	$148.10 - $198.00
Q3 2023	13,426	$2,377	$191.12	$168.65 - $218.88
Q4 2022	11,761	$3	$213.29	$181.65 - $242.97
Q3 2022	11,727	$2,297	$190.74	$135.46 - $236.80
Q2 2022	11,666	$1,700	$141.87	$117.58 - $180.35
Q1 2022	11,666	$1,959	$152.35	$125.00 - $174.66
Q4 2021	11,675	$1,529	$185.86	$154.82 - $212.00
Q3 2021	11,677	$2,319	$187.58	$166.16 - $209.73
Q2 2021	14,981	$2,951	$146.46	$125.08 - $177.53
Q1 2021	15,177	$2,075	$150.49	$124.00 - $178.41
Q4 2020	15,586	$2,686	$133.53	$119.29 - $148.76
Q3 2020	15,931	$2,100	$142.10	$119.67 - $167.33
Q2 2020	16,041	$2,534	$134.81	$98.01 - $158.37
Q1 2020	20,787	$3,027	$115.43	$84.97 - $134.51
Q4 2019	24,520	$2,831	$99.70	$73.32 - $125.72
Q3 2019	25,816	$2,295	$79.11	$69.11 - $88.00
Q2 2019	31,459	$2,286	$76.72	$65.81 - $96.08
Q1 2019	27,303	$2,482	$83.64	$70.29 - $93.95
Q4 2018	25,667	$2,031	$76.92	$60.27 - $90.00
Q3 2018	22,088	$1,692	$100.59	$86.95 - $124.22
Q2 2018	16,132	$1,649	$99.19	$87.35 - $118.71
Q1 2018	16,110	$1,549	$128.92	$108.13 - $153.99
Q4 2017	16,157	$2,164	$125.65	$111.25 - $147.63
Q3 2017	15,885	$1,953	$85.36	$70.76 - $119.02
Q2 2017	15,687	$1,310	$63.91	$46.90 - $86.92
Q1 2017	15,741	$831	$46.22	$35.98 - $60.41
Q4 2016	16,269	$677	$41.87	$31.38 - $71.67
Q3 2016	13,557	$491	$70.55	$53.56 - $80.11
Q2 2016	13,714	$1,048	$63.00	$49.96 - $75.08
Q1 2016	13,683	$941	$66.49	$51.51 - $98.00
Q4 2015	13,594	$1,151	$92.72	$71.14 - $110.75
Q3 2015	13,827	$1,111	$111.10	$76.46 - $137.89
Q2 2015	27,524	$3,298	$119.50	$98.63 - $140.00
Q1 2015	13,710	$1,431	$101.34	$82.06 - $121.93
Q4 2014	27,366	$2,654	$92.65	$72.80 - $111.49
Q3 2014	13,683	$1,068	$64.51	$51.93 - $79.88
Q2 2014	13,720	$867	$59.44	$47.03 - $71.40
Q1 2014	18,260	$1,226	$77.42	$60.24 - $112.57
Q4 2013	18,247	$1,174	$59.65	$48.16 - $67.97
Q3 2013	19,791	$1,267	$49.85	$31.75 - $65.83
Q2 2013	19,877	$616	$26.61	$21.60 - $31.79