ALNYLAM PHARMACEUTICALS INC

Ticker: ALNY CUSIP: 02043Q107 Class: EQTY

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014

Shares 29,100 Value ($000) $2,823 Avg Close $92.65 Range $72.80 - $111.49

Q3 2014

Shares 29,100 Value ($000) $2,272,710 Avg Close $64.51 Range $51.93 - $79.88

Q2 2014

Shares 7,200 Value ($000) $455 Avg Close $59.44 Range $47.03 - $71.40

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2014	29,100	$2,823	$92.65	$72.80 - $111.49
Q3 2014	29,100	$2,272,710	$64.51	$51.93 - $79.88
Q2 2014	7,200	$455	$59.44	$47.03 - $71.40