AMYLYX PHARMACEUTICALS INC

Ticker: AMLX CUSIP: 03237H101 Class: Common Stock

JANUS HENDERSON GROUP PLC's Holding History (CIK: 0001274173)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,465,872 Value ($000) $53,992 Avg Close $13.58 Range $11.69 - $16.96

Q3 2025

Shares 2,536,233 Value ($000) $34,455 Avg Close $9.41 Range $5.97 - $15.14

Q1 2024

Shares 14,717 Value ($000) $42 Avg Close $13.08 Range $2.67 - $19.95

Q4 2023

Shares 14,753 Value ($000) $217 Avg Close $15.33 Range $11.82 - $18.88

Q3 2023

Shares 14,754 Value ($000) $270 Avg Close $21.15 Range $17.80 - $25.48

Q2 2023

Shares 14,753 Value ($000) $318 Avg Close $27.01 Range $20.79 - $31.77

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,465,872	$53,992	$13.58	$11.69 - $16.96
Q3 2025	2,536,233	$34,455	$9.41	$5.97 - $15.14
Q1 2024	14,717	$42	$13.08	$2.67 - $19.95
Q4 2023	14,753	$217	$15.33	$11.82 - $18.88
Q3 2023	14,754	$270	$21.15	$17.80 - $25.48
Q2 2023	14,753	$318	$27.01	$20.79 - $31.77