| FMR LLC | 16,518,419 | $199,543 |
| BlackRock, Inc. | 9,054,431 | $109,378 |
| PERCEPTIVE ADVISORS LLC | 8,284,882 | $100,081 |
| TCG Crossover Management, LLC | 6,243,812 | $75,425 |
| VANGUARD GROUP INC | 5,804,912 | $70,123 |
| Commodore Capital LP | 5,650,000 | $68,252 |
| Saturn V Capital Management LP | 4,496,487 | $54,318 |
| JANUS HENDERSON GROUP PLC | 4,465,872 | $53,992 |
| First Light Asset Management, LLC | 3,355,539 | $40,535 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,109,503 | $37,563 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,777,055 | $33,547 |
| GOLDMAN SACHS GROUP INC | 2,613,221 | $31,568 |
| MORGAN STANLEY | 2,359,824 | $28,507 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,165,534 | $26,164 |
| Almitas Capital LLC | 2,122,597 | $25,641 |
| STATE STREET CORP | 2,069,884 | $25,004 |
| GREAT POINT PARTNERS LLC | 1,750,000 | $21,140 |
| 683 Capital Management, LLC | 1,650,000 | $19,932 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,513,148 | $18,279 |
| BANK OF AMERICA CORP /DE/ | 1,336,010 | $16,139 |
| DEUTSCHE BANK AG\ | 1,333,236 | $16,105 |
| FRANKLIN RESOURCES INC | 1,200,096 | $14,497 |
| Connor, Clark & Lunn Investment Management Ltd. | 1,004,021 | $12,129 |
| Logos Global Management LP | 950,000 | $11,476 |
| NORTHERN TRUST CORP | 937,764 | $11,328 |
| ADAR1 Capital Management, LLC | 890,356 | $10,756 |
| BALYASNY ASSET MANAGEMENT L.P. | 858,684 | $10,373 |
| Woodline Partners LP | 845,408 | $10,213 |
| Nantahala Capital Management, LLC | 835,684 | $10,095 |
| Boxer Capital Management, LLC | 800,000 | $9,664 |
| DIMENSIONAL FUND ADVISORS LP | 771,248 | $9,316 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 712,990 | $8,613 |
| STEMPOINT CAPITAL LP | 565,140 | $6,827 |
| UBS Group AG | 543,323 | $6,563 |
| Sofinnova Investments, Inc. | 527,099 | $6,367 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 506,242 | $6,115 |
| AMERIPRISE FINANCIAL INC | 502,366 | $6,069 |
| Rock Springs Capital Management LP | 499,764 | $6,037 |
| FEDERATED HERMES, INC. | 457,412 | $5,526 |
| Qube Research & Technologies Ltd | 412,873 | $4,988 |
| Cormorant Asset Management, LP | 400,000 | $4,832 |
| Parkman Healthcare Partners LLC | 381,760 | $4,612 |
| Patient Square Capital LP | 350,000 | $4,228 |
| CITADEL ADVISORS LLC | 344,968 | $4,167 |
| TWO SIGMA INVESTMENTS, LP | 344,401 | $4,160 |
| Point72 Asset Management, L.P. | 335,000 | $4,047 |
| ACUTA CAPITAL PARTNERS, LLC | 333,258 | $4,026 |
| TWO SIGMA ADVISERS, LP | 328,401 | $3,967 |
| Alpha Wave Global, LP | 317,678 | $3,838 |
| BARCLAYS PLC | 295,177 | $3,566 |
| Nuveen, LLC | 283,948 | $3,430 |
| Tetragon Partners GP Ltd | 272,828 | $3,296 |
| JANE STREET GROUP, LLC | 263,235 | $3,180 |
| ACADIAN ASSET MANAGEMENT LLC | 254,328 | $3 |
| HighVista Strategies LLC | 238,812 | $2,885 |
| WELLINGTON MANAGEMENT GROUP LLP | 225,782 | $2,727 |
| SummitTX Capital, L.P. | 218,399 | $2,638 |
| Bank of New York Mellon Corp | 217,347 | $2,626 |
| Aldebaran Capital, LLC | 198,508 | $2,398 |
| RENAISSANCE TECHNOLOGIES LLC | 192,500 | $2,325 |
| XTX Topco Ltd | 189,673 | $2,291 |
| Invesco Ltd. | 175,914 | $2,125 |
| Swiss National Bank | 161,700 | $1,953 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 153,363 | $1,853 |
| WELLS FARGO & COMPANY/MN | 146,309 | $1,767 |
| Atom Investors LP | 139,422 | $1,684 |
| BANK OF MONTREAL /CAN/ | 138,525 | $1,673 |
| PFM Health Sciences, LP | 134,549 | $1,625 |
| Numerai GP LLC | 112,648 | $1,361 |
| Elmind Capital, LP | 112,000 | $1,353 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 107,548 | $1 |
| RHUMBLINE ADVISERS | 99,274 | $1,199 |
| UBS ASSET MANAGEMENT AMERICAS INC | 98,838 | $1,194 |
| ALPS ADVISORS INC | 90,172 | $1,089 |
| STATE OF WISCONSIN INVESTMENT BOARD | 84,144 | $1,016 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,090 | $955 |
| Campbell & CO Investment Adviser LLC | 78,763 | $951 |
| Squarepoint Ops LLC | 76,562 | $925 |
| D. E. Shaw & Co., Inc. | 73,224 | $885 |
| Legal & General Group Plc | 72,612 | $877 |
| ALLIANCEBERNSTEIN L.P. | 71,500 | $864 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,892 | $832 |
| JPMORGAN CHASE & CO | 66,547 | $804 |
| Russell Investments Group, Ltd. | 65,438 | $790 |
| Kennondale Capital Management LLC | 53,423 | $645 |
| EAM Investors, LLC | 53,256 | $643 |
| SEI INVESTMENTS CO | 52,856 | $639 |
| MetLife Investment Management, LLC | 49,654 | $600 |
| Trexquant Investment LP | 48,112 | $581 |
| MILLENNIUM MANAGEMENT LLC | 46,455 | $561 |
| Mariner, LLC | 46,342 | $560 |
| PSP Research LLC | 44,223 | $534 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,166 | $497 |
| CITIGROUP INC | 38,032 | $459 |
| GSA CAPITAL PARTNERS LLP | 36,758 | $0 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,877 | $433 |
| FOX RUN MANAGEMENT, L.L.C. | 35,409 | $428 |
| INTECH INVESTMENT MANAGEMENT LLC | 32,006 | $387 |
| Persistent Asset Partners Ltd | 31,147 | $376 |
| Headlands Technologies LLC | 30,543 | $369 |
| 79 other institutions | 756,160 | $8,768 |