ANAPTYSBIO INC

Ticker: ANAB CUSIP: 032724106 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 670,288 Value ($000) $32,496 Avg Close $38.98 Range $29.48 - $52.47

Q3 2025

Shares 349,360 Value ($000) $10,697 Avg Close $22.95 Range $17.11 - $32.50

Q2 2025

Shares 112,349 Value ($000) $2,494 Avg Close $20.93 Range $15.40 - $24.86

Q1 2025

Shares 129,654 Value ($000) $2,410 Avg Close $16.68 Range $12.21 - $21.57

Q4 2024

Shares 197,107 Value ($000) $2,610 Avg Close $24.22 Range $12.51 - $36.54

Q3 2024

Shares 224,137 Value ($000) $7,509 Avg Close $34.16 Range $23.72 - $41.31

Q2 2024

Shares 171,450 Value ($000) $4,297 Avg Close $23.28 Range $18.49 - $27.02

Q1 2024

Shares 186,804 Value ($000) $4,207 Avg Close $23.68 Range $20.64 - $27.50

Q4 2023

Shares 160,326 Value ($000) $3,434 Avg Close $17.25 Range $13.36 - $22.39

Q3 2023

Shares 145,892 Value ($000) $2,620 Avg Close $19.08 Range $16.51 - $20.80

Q2 2023

Shares 205,796 Value ($000) $4,186 Avg Close $20.27 Range $18.01 - $23.05

Q1 2023

Shares 207,052 Value ($000) $4,505 Avg Close $24.30 Range $20.51 - $31.14

Q4 2022

Shares 174,198 Value ($000) $5,398 Avg Close $28.24 Range $25.12 - $32.44

Q3 2022

Shares 176,500 Value ($000) $4,503 Avg Close $23.44 Range $18.35 - $27.41

Q2 2022

Shares 131,152 Value ($000) $2,662 Avg Close $22.15 Range $18.20 - $26.89

Q1 2022

Shares 169,560 Value ($000) $4,195 Avg Close $30.26 Range $24.03 - $36.06

Q4 2021

Shares 212,681 Value ($000) $7,390 Avg Close $31.71 Range $26.46 - $37.89

Q3 2021

Shares 253,792 Value ($000) $6,883 Avg Close $25.38 Range $22.77 - $28.40

Q2 2021

Shares 258,644 Value ($000) $6,707 Avg Close $23.97 Range $19.91 - $26.80

Q1 2021

Shares 295,594 Value ($000) $6,370 Avg Close $25.24 Range $17.72 - $35.85

Q4 2020

Shares 564,925 Value ($000) $12,145 Avg Close $24.28 Range $14.55 - $31.29

Q3 2020

Shares 640,946 Value ($000) $9,454 Avg Close $18.04 Range $13.92 - $23.75

Q2 2020

Shares 699,767 Value ($000) $15,633 Avg Close $18.28 Range $13.06 - $24.30

Q1 2020

Shares 458,061 Value ($000) $6,473 Avg Close $15.17 Range $12.06 - $18.70

Q4 2019

Shares 365,391 Value ($000) $5,937 Avg Close $23.65 Range $10.00 - $39.48

Q1 2018

Shares 39,616 Value ($000) $4,123 Avg Close $112.70 Range $91.01 - $134.00

Q4 2017

Shares 5,128 Value ($000) $516 Avg Close $73.61 Range $34.56 - $102.63

Q3 2017

Shares 12,882 Value ($000) $450 Avg Close $26.97 Range $20.12 - $37.62

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	670,288	$32,496	$38.98	$29.48 - $52.47
Q3 2025	349,360	$10,697	$22.95	$17.11 - $32.50
Q2 2025	112,349	$2,494	$20.93	$15.40 - $24.86
Q1 2025	129,654	$2,410	$16.68	$12.21 - $21.57
Q4 2024	197,107	$2,610	$24.22	$12.51 - $36.54
Q3 2024	224,137	$7,509	$34.16	$23.72 - $41.31
Q2 2024	171,450	$4,297	$23.28	$18.49 - $27.02
Q1 2024	186,804	$4,207	$23.68	$20.64 - $27.50
Q4 2023	160,326	$3,434	$17.25	$13.36 - $22.39
Q3 2023	145,892	$2,620	$19.08	$16.51 - $20.80
Q2 2023	205,796	$4,186	$20.27	$18.01 - $23.05
Q1 2023	207,052	$4,505	$24.30	$20.51 - $31.14
Q4 2022	174,198	$5,398	$28.24	$25.12 - $32.44
Q3 2022	176,500	$4,503	$23.44	$18.35 - $27.41
Q2 2022	131,152	$2,662	$22.15	$18.20 - $26.89
Q1 2022	169,560	$4,195	$30.26	$24.03 - $36.06
Q4 2021	212,681	$7,390	$31.71	$26.46 - $37.89
Q3 2021	253,792	$6,883	$25.38	$22.77 - $28.40
Q2 2021	258,644	$6,707	$23.97	$19.91 - $26.80
Q1 2021	295,594	$6,370	$25.24	$17.72 - $35.85
Q4 2020	564,925	$12,145	$24.28	$14.55 - $31.29
Q3 2020	640,946	$9,454	$18.04	$13.92 - $23.75
Q2 2020	699,767	$15,633	$18.28	$13.06 - $24.30
Q1 2020	458,061	$6,473	$15.17	$12.06 - $18.70
Q4 2019	365,391	$5,937	$23.65	$10.00 - $39.48
Q1 2018	39,616	$4,123	$112.70	$91.01 - $134.00
Q4 2017	5,128	$516	$73.61	$34.56 - $102.63
Q3 2017	12,882	$450	$26.97	$20.12 - $37.62